Drosophila as a model for unfolded protein response research
نویسندگان
چکیده
منابع مشابه
Drosophila as a model for unfolded protein response research
Endoplasmic Reticulum (ER) is an organelle where most secretory and membrane proteins are synthesized, folded, and undergo further maturation. As numerous conditions can perturb such ER function, eukaryotic cells are equipped with responsive signaling pathways, widely referred to as the Unfolded Protein Response (UPR). Chronic conditions of ER stress that cannot be fully resolved by UPR, or con...
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Stress in the endoplasmic reticulum (ER stress) and its cellular response, the unfolded protein response (UPR), are implicated in a wide variety of diseases, but its significance in many disorders remains to be validated in vivo. Here, we analyzed a branch of the UPR mediated by xbp1 in Drosophila to establish its role in neurodegenerative diseases. The Drosophila xbp1 mRNA undergoes ire-1-medi...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2015
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2015.48.8.099